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Next, using mouse embryonic fibroblasts that lack syndecan-4, and thus have constitutively high levels of intracellular Ca 2+ due to dysregulation of TRPC7 channels 3 , we found that APTF-2::V5 nuclear localization is not overtly affected (Fig

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4-( N -( S -glutathionylacetyl)amino)phenylarsonous acid is a prospective cancer drug and has just completed a phase I dose escalation study in patients with solid tumors refractory to standard therapy (Horsley et al., 2013)

The mean absolute bioavailability following intramuscular injection was approximately 14-19% in rats and 45-51% in beagle dogs, suggesting species-specific absorption characteristics relevant for dose translation to human applications

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